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Lab Members

Carla Kim, PhD. - Principal Investigator

Dr. Kim is interested in the relationships between stem cell biology, cancer biology, and lung biology. Carla earned her doctorate in Genetics at the University of Wisconsin, Madison. As a graduate student in the laboratory of John Petrini, she studied the role of the Rad50 gene in DNA damage responses and homeostasis in vivo. She found that a point mutation in the murine Rad50 gene led to bone marrow failure (likely due to hematopoietic stem cell failure) as well as increased suseptibility to hematopoietic malignancy. These studies stimulated her interest in determining if stem cells played a role in the initiation of cancer. She went on to a postdoctoral position in the laboratory of Tyler Jacks at the Massachusetts Institute of Technology Center for Cancer Research. There, she developed a method to isolate the first stem cell population from the adult murine lung, termed bronchioalveolar stem cells (BASCs). She also showed that BASCs are critically affected by an oncogenic K-ras mutation and may be the cell-of-origin of lung adenocarcinomas.

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Post-Doctoral Fellows

Christine Fillmore, PhD

Chris is interested in elucidating epigenetic mechanisms that control lung cancer subtype and disease resistance. She studied microbiology at Middlebury College and became interested in cancer genetics while working at Dana-Farber Cancer Institute as a technician. She then earned her Ph.D. at Tufts University Sackler School where she studied breast cancer stem cells.

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Kristen Tropea Leeman, MD

Kristen is a board certified Pediatrician and Instructor in Pediatrics at Harvard Medical School. She received her BS with Honors in Chemistry from University of North Carolina at Chapel Hill. She received her MD from the University of Virginia and completed pediatric residency training at University of North Carolina Children's Hospital. Kristen joined the lab in July 2010 and is interested in studying the role of BASCs in physiologic lung development and lung injury.

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Samuel Rowbotham, PhD

Sam received his Bsc in Genetics from the University of York in 2007. He then received his PhD from the University of Cambridge in 2011 for his work on the role of chromatin remodeling proteins in the replication of epigenetic modifications. Sam joined the lab in December 2011 and is studying the relationship between the epigenetic control of self-renewal and differentiation of lung stem cells and lung cancer stem cells.

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Carolina Garcia de Alba Rivas, MD PhD

Carolina received her MD from the Universidad Autonoma de Baja California in Mexicali, she has a Masters degree in Epidemiology and received her PhD in biomedical sciences from the Universidad Nacional Autonoma de Mexico where she studied the participation of hematopoietic progenitor cells in the pathogenesis of Idiopathic Pulmonary Fibrosis, under the mentorship of Dr. Moises Selman. She joined the Kim lab in April 2014 and is interested in studying the effect of chronic epithelial injury on the regenerative capacity of endogenous lung stem and progenitor cells.

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Lisa Li, PhD

Lisa received her mastesr degree from Nagoya Institute of Technology and her Ph.D. from Shinya Yamanaka’s lab in Kyoto University, Japan. Her graduate studies focused on developing novel technologies to genetically engineer stem cells for gene therapy. She joined the Kim lab and the Daley lab in July 2015 and is studying targets for cystic fibrosis using stem cell and gene editing technologies.

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Margherita Paschini, PhD

Margherita received her bachelor and master degrees in Molecular Biotechnology from the University of Bologna, Italy. She then obtained her PhD from the University of California, San Diego working on the replication of yeast telomeres at the Salk Institute in La Jolla, California. She joined the Kim lab in August 2015 and she is currently focused on the paracrine signaling occurring in the pulmonary niche after injury and during cancer progression.

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Lab Manager

Patrizia Pessina, PhD

Patrizia received her Masters of Science in Biological Sciences and her PhD in Translational and Molecular Medicine from the University of Milano Bicocca. She completed her postdoctoral fellowship in the Canoves Lab at the University of Pompeu Fabra where she studied the Mechanisms and treatments of muscle fibrosis. She joined the Kim Lab in April of 2016.

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Research Technicians

Kelly Bellaria

Kelly joined the Kim Lab in October of 2012. She graduated from Boston College with a degree in Biology.

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Administrative Associate

Cheena Yadav

Cheena joined the Kim Lab in late August 2016. She provides administrative support to Kim Lab. She graduated from Purdue University and Indiana University with degree in Biology and Health policy management.

 

Bryan Marsh

Bryan joined the Kim Lab in September of 2015. He graduated from Weslyan University with a degree in Biology. He is now a graduate student at University of California, San Francisco

 

Joanne Berry

Joanne joined the Kim Lab in July of 2014. She graduated from Ohio Nothern University with a degree in Biochemistry.

Joo-Hyeon Lee, PhD

Joo-Hyeon received her Ph.D. in Molecular Genetics from KAIST, Korea, where she studied the molecular mechanisms of cell cycle regulation with knockout mouse models. She joined the lab in March 2009 and pursued the understanding of the role of the microenvironment in BASC regulation and lung tumorigenesis. Joo-Hyeon is now a Sir Henry Dale Fellow and Principal Investigator at the Stem Cell Institure at the University of Cambridge.

Jed Mahoney, PhD

Jed received his BA from Colby College and his Ph.D. from the Boston University School of Medicine as part of Wellington Cardoso’s Lab. His graduate studies focused on the role of YAP during development of the airway epithelium. He joined the Kim lab in July 2014 and studied the different populations of stem/progenitor cells in the lung and how they contribute to injury repair. He now is a Senior Scientist I at Cystic Fribrosis Foundation Therapeutics.

Kerstin Sinkevicius, PhD

Kerstin joined the lab in January 2008 and is studied the role of cancer stem cells in human lung cancer growth, recurrence, and metastasis. She graduated with a degree in chemistry from Grinnell College in 2001 and received her PhD in cancer biology from the University of Chicago in 2007. She is now a Research Scientist II at Synageva BioPharma Corp

Allison Lau, PhD

Allison completed her undergraduate degree in Biology from the Pennsylvania State University, where she studied phylogenetics in the lab of Dr. Kateryna Makova. She received her PhD from the Biological and Biomedical Sciences Program at Harvard Medical School, she joined the Kim Lab in 2009. Allison is completing her Postdoctoral fellowship at MIT. Allison is interested in the link between lung tumor propogating cells and metastisis.

Pooja Desai

Pooja joined the Kim Lab in September of 2013. She is currently an undergraduate at Boston University studying Biochemistry and Molecular Biology, as well as International Relations. She studied the effects of EZH2 deletion on tumor formation.

Alex Beede

Alex joined the Kim Lab in June of 2012. He graduated from Tufts University with a degree in Biology and History.

Sarah Lawler

Sarah provided administrative support for the Kim Lab from 2012-2013. She is currently working as a Special Education Teaching Assistant at Center School in Hopkinton, MA.

Sima Zacharek, PhD

Sima completed her graduate studies in Genetics and Molecular Biology at the University of North Carolina in Chapel Hill. Since joining the lab in November of 2006 she has become interested in the molecular mechanisms regulating BASCs, and in the development of genetic tools to study BASC function in vivo. Sima is now a staff scientist at the Belfer Institute of Applied Cancer Science in Boston, MA.

Christina Kriegel, PhD

Christina earned her PhD in Food Nanotechnology in September 2008 from University of Massachusetts at Amherst. The studies she focued on included electrospinning of biopolymeric nanofibers in the presence of surfactant and surfactant micelles.
Following her studies at UMass, Christina went on to a postdoctoral fellowship at Northeastern University where she worked to develop polymeric gene silencing delivery systems to target disease sites. As a member of the Kim Lab, Christina was interested in cancer stem cells and their role in lung cancer. Christina is now a postdoc in Tarek Fahmy's lab at Yale University in Connecticut, studying the development and understanding of novel nano-materials for cancer immunotherapy and stem cell therapy.

Stephen Curtis, PhD

Steve defended his doctoral thesis in September of 2011. Steve joined the Kim Lab in 2007 as a graduate student in the department of Biological and Biomedical Sciences at Harvard Medical School. Steve's work in the Kim Lab was published in a first-author paper in Cell Stem Cell, identifying genetic markers for tumor-propagting cells in some lung cancer tumors. Steve is now an Analyst at Reata Pharmaceuticals in Irving, Texas.

Juliana Barrios

Juliana graduated from Simmons College with a Bachelors in Biochemistry. She joined the Kim Lab in September 2010 and worked with Kerstin Sinkevicius, PhD.

Alan Chou

Alan joined the lab through the HSCI Summer Undergraduate Research Program in 2007. Alan performed studies to validate gene expression data in lung tissue sections. He graduated as a Pre-Med majoring in Biology at Harvard University. In September 2010, Alan began medical school at Columbia University in New York, NY.

John Campbell

John graduated with highest honors from NC State in 2011. He is continuing his education in laboratory science at the National Institutes of Health. He joined the Kim Lab through the Summer Honors Undergraduate Research Program at Harvard Medical School in the summer of 2010.

David Gludish

David earned his undergraduate degree in Biochemistry and a Master of Science, Biochemsitry degree both at McMaster University in Ontario, Canada. He lives in Ithaca, New York and is in the DVM-PhD program at Cornell.

Eva Leder, MD

Eva is a board certified Pediatrician and graduated as a clinical fellow in Pediatric Pulmonology at Children's Hospital Boston. She received her MD from the Universtiy of Vienna, Austria and completed pediatric residency training at Schneider Children's Hospital, Albert Einstein school of Medicine in New York. Eva joined the lab in July 2008 and studied the role of BASCs in physiologic lung development and lung injury.

Elizabeth "Libby" Perry

Libby provided administrative support for the Kim Lab from 2010-2012. She is currently the Program Coordinator in the Division of GI/Nutrition at Boston Children's Hospital.

Dave Raiser

Dave completed his undergraduate studies at the University of Richmond, where he studied biology. In the Kim lab, he worked on the development of a lung stem cell transplantation model. Dave is currently a student in the BBS Program at Harvard Medical School.



Morgan Matthews

Morgan is a sophomore biology major at Harvard University. She first came to the Kim Lab in the summer of 2011 through the Harvard Stem Cell Institute's Summer Internship Program. Morgan conducted her undergraduate research in the lab studying the molecular mechanisms regulating lung injury repair.

Arven Saunders

Arven has finished his master’s degree in molecular biology at Harvard Extension School in the Kim Lab. He attended Brandeis University where he earned his bachelor’s degree in biology in 2006 and attends the Mt. Sinai School of Medicine in New York, NY.

Rebecca Roach

Becca was the first member of our lab and joined after completing her undergraduate degree in Biology from the University of Central Oklahoma. Becca received a Masters of Public Health from the Boston University School of Public Health in 2011 and is currently a medical student at Western Univeristy College of Osteopathic Medicine in Oregon.

Janice Wong

Janice joined the Kim Lab in November of 2010. She graduated from the University of Massachusetts at Amherst, where she also earned her M.S. Janice is currently applying to medical schools.

Raffaella Zamponi

Raffaella earned her master's degree in Biotechnology at D'Annunzio University in Italy. She joined the lab in March 2009 and she studied genetic approaches to investigate cancer stem cells in lung adenocarcinoma.  

 

 

Student Interns

Centura Anbarasu
Centura completed a summer internship in the Kim Lap has part of the HSCI Internship program. She is an undergraduate studnet at Texas A&M.

Kwadwo Owusu-Boaitey
Kwadwo completed a rotation in our lab in 2014. He is a member of the Harvard BBS Program and is continuing his rotations.

Adam Pissaris
Adam completed an internship in our lab in 2014. He is an undergraduate student at Yale University

Flora Luo
Flora completed a rotation in our lab in 2011. She is a member of the Harvard BBS Program and is continuing her rotations.

Sarah Naomi Olsen
Naomi completed a rotation in our lab in 2011. She is a member of the Harvard BBS Program and is continuing her rotations.

Abby Sarkar
Abby completed a rotation in our lab in 2009. She is a member of the Harvard BBS Program and the Konrad Hochedlinger Lab.

Annie Phuong Vo
Annie completed a rotation in our lab in 2008. She is a member of the Harvard BSS Program and Raghu Kalluri's lab.

Suzanne Nizza
Suzanne completed a rotation in our lab in 2008. She is a member of the Harvard BBS Program and the James Campbell Lab.

Emrah Er
Emrah completed a rotation in our lab in 2007. He is a member of the Harvard BBS Program and the John Blenis Lab.

 

To apply for a position in the Kim Lab:
Send a curriculum vitae and request three references letters to be sent to:
Carla Kim