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Selected Publications:

  • Fillmore CM, Xu C, Desai PT, Berry JM, Rowbotham SP, Lin YJ, Zhang H, Marquez VE, Hammerman PS, Wong KK, Kim CF. 2015. EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumors to TopoII inhibitors. Nature. 520(7546):239-42. PMID: 25629630, PMCID: PMC4393352.
  • Xu C, Fillmore CM, Koyama S, Wu H, Zhao Y, Chen Z, Herter-Sprie GS, Akbay EA, Tchaicha JH, Altabef A, Reibel JB, Walton Z, Ji H, Watanabe H, Jänne PA, Castrillon DH, Rustgi AK, Bass AJ, Freeman GJ, Padera RF, Dranoff G, Hammerman PS,* Kim CF,* Wong KK.* (2014) Loss of Lkb1 and Pten Leads to Lung Squamous Cell Carcinoma with Elevated PD-L1 Expression. Cancer Cell. 25:590-604. PMID: 24794706 PMCID: PMC4112370 *Co-corresponding authors
  • Sinkevicius KW, Kriegel C, Bellaria KJ, Lee J, Lau AN, Leeman KT, Zhou P, Beede AM, Fillmore CM, Caswell D, Barrios J, Wong KK, Sholl LM, Schlaeger TM, Bronson RT, Chirieac LR, Winslow MM, Haigis MC, Kim CF. (2014). Neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis. Proceedings of the National Academy of Sciences of the USA. pii: 201404399. PMID: 24982195, PCMID: PMC4104511.
  • Lau AN, Curtis SJ, Fillmore CM, Rowbotham SP, Mohseni M, Wagner DE, Beede AM, Montoro DT, Sinkevicius KW, Walton ZE, Barrios J, Weiss DJ, Camargo FD, Wong KK, Kim CF. EMBO J. 2014 Jul 1;33(13):1502. doi: 10.15252/embj.201488991. No abstract available. PMID: 24986897, PMCID: PMC3989628.
  • Lee JH, Bhang DH, Beede A, Huang TL, Stripp BR, Bloch KD, Wagers AJ, Tseng YH, Ryeom S, Kim, CF. Lung stem cell differentiation in mice directed by endothelial cells via a BMP4-NFATc1-Thrombospondin-1 axis. Cell, 2014; 156(3):440-455. PMCID: PMC3951122.
  • Lee JH, Kim J, Gludish D, Roach RR, Saunders AH, Barrios J, Woo AJ, Chen H, Conner DA, Fujiwara Y, Stripp B, Kim CF. (2012). SPC H2B-GFP mice reveal heterogeneity of surfactant protein C-expressing lung cells. Am. J. Respir. Cell Mol. Biol., 48(3):288-98. PMCID: PMC3604082
  • Chen H, Matsumoto K, Rackley CR, Brockway BL, Kim CF, Lee JH, Stripp BR. (2012) Airway Epithelial Progenitors are Region-Specific and Show Differential Responses to Bleomycin-Induced Lung Injury. Stem Cells, 30(9):L829-37.
  • Tropea K, Leder E, Aslam M, Lau A, Raiser D, Lee J, Balasubramaniam V, Frendenburgh L, Mitsialis S, Kourembanas S, Kim CF. (2012) Bronchioalveolar stem cells increase after mesenchymal stromal cell treatment in a mouse model of bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol, 302(9):L829-37.
  • Zacharek SJ, Fillmore CF*, Lau AN*, Gludish DW*, Chou A, Ho JWK, Zamponi R, Gazit R, Bock C,Jäger N, Smith ZD, Kim T, Saunders AH, Wong J, Lee JH, Roach RR, Rossi DJ, Meissner A, Gimelbrant AA, Park PJ, Kim CF. (2011). Lung stem cell self-renewal relies on Bmi1-dependent control of expression at imprinted loci. Cell Stem Cell 9(3): 272-81. *Equal contribution as second author
  • Park KS, Liang MC, Raiser DM, Zamponi R, Roach RR, Curtis SJ, Walton Z, Schaffer BE, Roake CM, Zmoos AF, Kriegel C, Wong KK, Sage J*, Kim CF*. (2011). Characterization of the cell of origin for small cell lung cancer. Cell Cycle 10(16): 2806–15. * Co-corresponding authors
  • Curtis SJ, Sinkevicius KW, Li D, Lau AN, Roach RR, Zamponi R, Woolfenden AE, Kirsh DG, Wong KK, Kim CF. (2010) Primary tumor genotype is an important determinant in identification of lung cancer propagating cells. Cell Stem Cell; 7(1): 127-133.
    Press Release for Cell Stem Cell Paper July 2010
  • Dovey J, Zacharek SJ, Kim CF*, Lees JA*. (2008) Bmi1 is critical for lung tumorigenesis and bronchioalveolar stem cell expansion. Proc. Natl. Acad. Sc; 105(33):11857-62. *Co-corresponding authors
  • Nolen-Walston RD*, Kim CF*, Mazan MR, Ingenito EP, Gruntman AM, Tsai L, Boston R, Woolfenden AE, Jacks T, Hoffman AM. (2008) Cellular kinetics and modeling of bronchioalveolar stem cell response during lung regeneration. American Journal of Physiology: Lung Cellular and Molecular Physiology; 294(6):L1158-65. *equal contribution as first author
  • Kim CFB, Jackson EL, Woolfenden AE, Lawrence S, Babar I, Vogel S, Crowley D, Bronson RT, Jacks T. (2005) Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell; 121:823-35.

Reviews:

  • Chen Z, Fillmore CM, Hammerman PS, Kim CF, Wong KK. Nat Rev Cancer. 2014 Jul 24;14(8):535-46. doi: 10.1038/nrc3775.
  • Rowbotham SP, Kim CF. Diverse cells at the origin of lung adenocarcinoma. Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):4745-6. doi: 10.1073/pnas.1401955111. Epub 2014 Mar 20.
  • Lau AN, Goodwin M, Kim, CF, Weiss DJ. Stem cells and regenerative medicine in lung biology and diseases. Mol Ther. 2012 Jun;20(6):1116-30.
  • Sinkevicius KW, Curtis SJ, Kim CF. (2009) Examining the cancer stem cell hypothesis in human lung cancers. Lung Cancer: Principles and Practice, 4th Edition,  Pass HI, Carbone DP, Johnson DH, Minna JD, Turrisi AT, Scagliotti GV (eds), Philadelphia: Lippincott-Williams-Wilkins; 165-172.

  • Alexander CM Puchalski J, Klos KS, Badders N, Ailles L, Kim CF, Dirks P, Smalley MJ. (2009) Separating stem cells by flow cytometry: reducing variability for solid tissues. Cell Stem Cell; 5:579-583
  • Raiser DM, Kim CF. (2009). Sca-1 and Cells of the Lung: A Matter of Different Sorts. Stem Cell; 27:606-611.
  • Raiser DM, Zacharek SJ, Roach RR, Curtis SJ, Sinkevicius KW, Gludish DW, Kim CF. (2008) Stem cell biology in the lung and lung cancers: employing pulmonary context and classic approaches. Cold Spring Harbor Symposium Quant Biol; 73:479-90.

  • Kim CF*, Dirks PB*. (2008) Cancer and stem cell biology: how tightly intertwined? Cell Stem Cell; 3:147-50. *co-corresponding authors

  • Kim CF. (2007) Paving the road for lung stem cell biology: bronchioalveolar stem cells and other putative distal lung stem cells. Am J Physiol Lung Cell Mol Physiol; 296:L1092-8.

  • Kim, CFB. (2007) Advancing the field of lung stem cell biology. Frontiers in Bioscience; 12:3117-3124.

  • Kim, CFB, Jackson EL, Kirsch DG, Grimm J, Shaw AT, Lane K, Kissil J, Olive KP, Sweet-Cordero A, Weissleder, Jacks T. (2005) Mouse models of human non-small-cell lung cancer: raising the bar. Cold Spring Harbor Symposia on Quantitative Biology; Volume LXX:241-250.

Collaborations:

  • Yu M, Mazor T, Huang H, Huang HT, Kathrein KL, Woo AJ, Chouinard CR, Labadorf A, Akie TE, Moran TB, Xie H, Zacharek S, Taniuchi I, Roeder RG, Kim CF, Zon LI, Fraenkel E, Cantor AB. Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors. Mol Cell. 2012; 45(3): 330-43.
  • Carretero J, Shimamura T, Rikova K, Jackson AL, Wilkerson MD, Borgman CL, Buttarazzi MS, Sanofsky BA, McNamara KL, Brandstetter KA, Walton ZE, Gu TL, Silva JC, Crosby K, Shapiro GI, Maira SM, Ji H, Castrillon DH, Kim CF, García-Echeverría C, Bardeesy N, Sharpless NE, Hayes ND, Kim WY, Engelman JA, Wong KK (2010) Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors. Cancer Cell; 17(6): 547-59.
  • Hoffman AM, Shifren A, Mazan MR, Gruntman AM, Lascola K, Nolen-Walston R, Kim CF, Tsai L, Pierce RA, Mecham RP, Ingenito EP. (2009) Matrix modulation of compensatory lung regrowth and progenitor cell proliferation in mice.  American Journal of Physiology:  Lung cellular and molecular physiolog; 298(2):L158-68.
  • Yang Y, Iwanaga K, Raso MG, Wislez M, Hanna AE, Wieder ED, Molldrem JJ, Wistuba II, Powis G, Demayo FJ, Kim CF, Kurie JM. (2008) Phosphatidylinositol 3-Kinase Mediates Bronchioalveolar Stem Cell Expansion in Mouse Models of Oncogenic K-ras-induced Lung Cancer. PLoS ONE; 3:e2220.

  • Perera SA, Maser RS, Xia H, McNamara K, Protopopov A, Chen L, Hezel A, Kim CF, Bronson RT, Castrillon DH, Chin L, Bardeesy N, Depinho RA, Wong KK. (2008) Telomere dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung cancer. Carcinogenesis; 29(4):747-53.
  • Kissil JL, Walmsley MJ, Hanlon L, Haigis K, Kim CFB, Sweet-Cordero A, Eckman MS, Tuveson DA, Capobianco AJ, Tybulewicz VLJ, Jacks T. (2007) Requirement for Rac1 in a K-ras–Induced Lung Cancer in the Mouse. Cancer Research; 67:8089-8094.

  • Ji H, Houghton AM, Mariani TJ, Perera S, Kim CF, Padera R, Tonon G, McNamara K, Marconcini LA, Hezel A, El-Bardeesy N, Bronson RT, Sugarbaker D, Maser RS, Shapiro SD, Wong KK. (2006) K-ras activation generates an inflammatory response in lung tumors. Oncogene; 25:2105-12.